Novel Method for the Spectrophotometric Determination of Isoniazid and Ritodrine Hydrochloride

Pyridine-4-carboxylic acid hydrazide, commercially known as isoniazid (INH), is an antitubercular drug and is now widely used together with rifampicin and streptomycin for the chemotherapy of tuberculosis. Ritodrine hydrochloride (RTH), chemically, 1-(4-hydroxyphenyl)-2-[2-(4-hydroxyphenyl)ethylamino]propanol is a potent tocolytic drug and is a selective β2-adrenoceptor agonist and is used to control premature labour and to reverse foetal distress caused by excessive uterine activity. The importance of these two drugs has prompted many investigators to devise methods for the rapid determination of INH/RTH in its pure form as well as in pharmaceutical preparations. There are various analytical procedures for the assay of INH, may of which were reviewed in one of our earlier works on the spectrophotometric determination of isoniazid. The spectrophotometric reagents for the determination of isoniazid include sodium 1,2-naphthoquinone-4-sulphonate and cetyltrimethyl ammonium ∗Corresponding author